Is NMNH Better Than NMN?

As the science of longevity grows and people seek to live longer, supplements like NMN (nicotinamide mononucleotide) and NMNH (reduced nicotinamide mononucleotide) have gained attention for their apparent effectiveness in boosting NAD+ levels, promoting cellular health, and fighting the effects of aging.

Both compounds are closely related to NAD+ (nicotinamide adenine dinucleotide), a molecule essential for energy production and cellular repair.

As a consumer, you might ask if NMNH is better than NMN? AIDEVI Supplements looks at the key differences between these two compounds. They look at how each one works and what current research says about their effectiveness.

For a good anti-aging solution or to improve your health, it’s important to understand NMN and NMNH. This knowledge will help you make a smart choice.

What are NMN and NMNH?

NMN: A Well-Studied NAD+ Booster

Nicotinamide mononucleotide (NMN) is a natural compound that plays an important role in increasing NAD+ (nicotinamide adenine dinucleotide) levels in the body.

As NAD+ levels naturally decline with age. This increase can improve mitochondrial capacity, DNA repair, and overall cellular health. Many studies show that NMN helps heart health. It also improves insulin sensitivity and muscle function.

However, as people age, they gradually fail to get enough NMN from their daily food. The demand for NMN is growing. It can raise NAD+ levels, which is good, but the effect levels off quickly.

Want to know more about the secrets of NMN, this article can help you: Everything You Need to Know About NMN Supplement

NMNH: The new darling of the market?

Nicotinamide mononucleotide (NMNH), also known as reduced NMN, is a higher-order derivative in the family of NAD+ precursors. Similar to NMN, NMNH is a naturally occurring compound.

As we age, NAD+ levels decline, leading to decreased mitochondrial function, impaired DNA repair, and accelerated cellular aging. NMNH is a more directly effective version of NMN. It has special properties that make it more stable.

This stability may help increase NAD+ levels. Recent studies show that NMNH may offer better bioavailability at the same doses as NMN. This leads to more effective NAD+ supplementation.

This boost helps improve mitochondrial performance, improves DNA repair mechanisms, and overall increases cellular viability. In addition, NMNH shows promise in promoting cardiovascular health, enhancing insulin sensitivity, and improving muscle function.

As we age, we are unable to solely restore NMN and NMNH through our diet. For a quick boost in NAD+ for anti-aging, NMNH might be a better option. It can help overcome the limits of rapid stagnation during supplementation.

On the downside, NMNH is relatively new, so the number of long-term human studies is limited. Early data suggests it might be more effective than NMN. However, the lack of extensive clinical data may make many consumers cautious. Some may still choose NMNH supplement because they believe they are more effective.

Benefits & Side Effects Comparison

To make it easier to compare, this article presents a table. It clearly shows the differences between NMN and NMNH.

Health Benefits	NMNH	NMN
More Energy	Increases NAD+ levels, providing cells with more energy.	Raises NAD+ levels, enhancing metabolism and energy production.
Healthy Metabolism	Helps regulate metabolism, aiding in weight control and health maintenance.	Enhances metabolism, supporting energy production and overall health.
DNA Repair	Supports DNA repair, potentially slowing down aging processes.	Contributes to DNA repair, aiding in maintaining cell health and youthfulness.
Brain Protection	May protect brain cells, reducing the risk of brain-related issues.	Linked to brain cell protection, potentially preventing cognitive decline.
Heart Health	Supports cardiovascular health by improving blood flow and reducing stress.	Linked to better heart function and reduced risk of heart disease.
Side Effects and Safety	NMNH	NMN
Common Issues	Some users may experience mild digestive problems like nausea or stomach upset.	Users might encounter mild side effects such as digestive discomfort, headaches, or flushing.
Long-Term Safety	Research suggests it's generally safe for long-term use, but more studies are needed.	Extensively studied and appears safe for extended use, but ongoing research is essential for confirmation.

Both NMNH and NMN offer valuable health benefits by boosting NAD+ levels, albeit with slightly different effects and safety profiles. Understanding these differences can help individuals choose the right supplement for their health goals.

The Significant Question: What Should We Choose?

Which One Is Right for Me?

Both NMN supplement and NMNH supplement can help improve cellular health and fight age-related decline. Choosing the right one for your daily routine depends on your priorities:

For a well-researched, reliable option: NMN is likely the safer choice. It has a long history of research. Many studies show its benefits for metabolism, heart health, and energy production. (How to choose the right NMN supplement for you?)

For a more potent, cutting-edge supplement: NMNH provides faster, stronger effects in a smaller dose. This product is newer to the market and has less long-term research. It is the best choice for those looking for a quick, short-term boost.

Can you use NMN and NMNH together?

In theory, combining NMN and NMNH may offer complementary benefits. While NMN provides a steady, sustained boost in NAD+ levels, NMNH serves as a quick source of supplementation for immediate needs.

For people facing high stress, recovering from illness, or doing tough physical work, NMN and NMNH can be helpful. They collaborate effectively together. Their combined effects may help improve recovery and performance.

However, there is limited research on the combination of the two, and uncertainty exists. Always consult a healthcare professional before combining supplements to ensure safety and effectiveness.

Tailor Your Choice to Your Personal Health Goals

Ultimately, choosing between NMN and NMNH (or using both) comes down to your unique health goals. Are you looking for a steady anti-aging solution, or do you need faster recovery and repair? Is affordability an important concern, or do you prioritize cutting-edge science? By knowing your goals, lifestyle, and health needs, you can choose the best NAD+-boosting supplement

Conclusion

NMN and NMNH are beneficial dietary additions. They help increase levels of NAD+. NAD+ is important for energy production and cell repair. 

NMN is a well-researched option that is ideal for sustained support of cardiovascular health, metabolism, and energy. NMNH provides better bioavailability and quicker NAD+ replenishment. This makes it great for people wanting a fast way to fight age-related cellular decline.

Explore the options available and match them to your health goals. Before you choose a supplement to improve your cellular health or fight aging, consult with a healthcare professional. They can help you find the best approach. 

If you have anti-aging needs, AIDEVI's range of NMN supplement and NMNH supplement ensures you find a solution that fits your unique needs. Begin your journey towards enhanced wellness immediately!

Reference

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3. Varela, C., and J. Mifsud. "P-255: Nicotinamide Mononucleotide (NMN) During Gestational Diabetes Mellitus (GDM)." Placenta, vol. 105, 2021, pp. A129–A130. Semantic Scholar, https://www.semanticscholar.org/paper/P-255%E2%80%83Nicotinamide-mononucleotide-(NMN)-during-(GV)-Varela-Mifsud/b13aef300fd8a6afb9fdc10be40bbed5b6f97451.

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5. Nadtochiy, Sergey M., and Richard Wang. "Nicotinamide Mononucleotide (NMN) Affords Cardioprotection by Improving Mitochondrial Bioenergetics." Semantic Scholar, https://www.semanticscholar.org/paper/Nicotinamide-mononucleotide-(NMN)-affords-by-Nadtochiy-Wang/8a8f038a95f4b41f99efe9165eddb10074414b41.

6. Ghosh, Shibani, et al. "Nicotinamide Mononucleotide Supplementation Mitigates Chronic Kidney Disease Progression by Restoring NAD+ Levels and Improving Mitochondrial Function." Kidney International, vol. 103, no. 3, 2023, pp. 500–514. PubMed, https://pubmed.ncbi.nlm.nih.gov/36636898/.

7. Yao, Hongbo, et al. "Nicotinamide Mononucleotide (NMN) Supplementation Ameliorates Age-Related Cognitive Decline and Promotes Brain Mitochondrial Function in Mice." FASEB Journal, vol. 35, no. 8, 2021, e021826R. Wiley Online Library, https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001826R.