AIDEVI NMN 18000 — High-Potency NAD+ Booster & Anti-Aging Supplement

At the heart of the formula is ≥99% purity β-NMN, the biologically active form of Nicotinamide Mononucleotide. At 300 mg per capsule (600 mg per serving), AIDEVI NMN 18000 delivers a clinically relevant dose aligned with the dosage ranges studied in human trials. Each capsule provides the NAD+ precursor substrate that cells require to regenerate this critical coenzyme.

A 2022 randomised controlled trial in Frontiers in Aging found that NMN supplementation at doses of 300–600 mg/day significantly increased blood NAD+ levels and improved physical performance markers in healthy adults. A 2024 study published in Nutrients further demonstrated that NMN intake maintained walking speed and improved sleep quality in older adults — confirming real-world functional benefits beyond simple biomarker improvements.

Trans-Resveratrol is a naturally occurring polyphenol found in red grapes and berries, and a well-studied activator of SIRT1 — the primary sirtuin protein that NMN-derived NAD+ helps power. The combination of NMN and Resveratrol creates a powerful synergy: NMN provides the NAD+ substrate that SIRT1 requires as a cofactor, while Resveratrol directly activates SIRT1's deacetylase activity. Research published in Nutrients (2023) confirmed that this combination may improve DNA repair, mitochondrial function, and metabolic health beyond what either compound achieves alone.

TMG is a critical methyl donor that addresses a key biochemical consideration in NMN supplementation. As NMN is converted to NAD+ and subsequently consumed by sirtuin and PARP enzymes, it generates nicotinamide, which is then methylated and excreted. This process can deplete the body's methyl group reserves over time. TMG donates methyl groups to replenish this pool, ensuring that the methylation cycle — essential for gene expression, cardiovascular health, and liver function — remains uninterrupted. Including TMG alongside NMN represents a thoughtful, evidence-informed approach to long-term supplementation safety.

BioPerine® is a patented black pepper extract standardised to 95% piperine, clinically demonstrated to enhance the bioavailability of co-administered nutrients by up to 20% through inhibition of intestinal and hepatic metabolism. Its inclusion ensures that the NMN, Resveratrol, and TMG in each capsule are absorbed more completely and efficiently, maximising the return on every dose.

The "18000" refers to the total milligrams of NMN contained in the entire bottle — not the amount per capsule. Each bottle contains 60 capsules, each providing 300 mg of pure β-NMN. Multiplied together: 60 × 300 mg = 18,000 mg total. This naming convention is widely used in the NMN supplement industry to allow consumers to compare the total NMN content across different products at a glance. Per the standard suggested serving of 2 capsules per day, each bottle provides a 30-day supply at 600 mg NMN per day.

The timeline varies by individual, but published clinical data and user experience suggest the following general pattern. Blood NAD+ levels begin rising within the first 1–2 weeks of consistent supplementation, as confirmed by the NAD-brain pharmacokinetic study (2026). Subjective improvements in energy, mental clarity, and sleep quality are typically reported between weeks 3 and 6. More significant benefits related to physical performance, metabolic health, and skin vitality generally become apparent after 8–12 weeks of consistent daily use.

For best results, we recommend taking AIDEVI NMN 18000 consistently every morning and pairing it with a balanced diet, regular physical activity, and adequate sleep — the lifestyle factors that synergise most powerfully with NAD+ restoration.

NMN has an excellent safety profile in human studies. A comprehensive review of clinical trials found that oral NMN supplementation at doses up to 1,200 mg per day was well-tolerated with no serious adverse effects reported. A 2024 long-term safety study published in PubMed confirmed that NMN safely and effectively boosted NAD+ biosynthesis in healthy middle-aged adults over an extended period.

Some individuals may experience mild, transient digestive discomfort when first starting NMN supplementation, which typically resolves within the first week. As with any dietary supplement, consult your healthcare provider before use if you are pregnant, nursing, taking prescription medications, or managing a chronic health condition.

We recommend taking AIDEVI NMN 18000 in the morning, ideally on an empty stomach, to align with the body's natural circadian rhythms of NAD+ metabolism. NAD+ plays a key role in regulating the circadian clock, and morning dosing may help synchronise supplementation with peak cellular energy demand. Taking NMN with water 20–30 minutes before breakfast is a practical routine that most users find easy to maintain. Avoid taking NMN in the evening, as the energy-boosting effects may interfere with sleep onset in some individuals.

Trans-Resveratrol is included because it directly activates SIRT1, the sirtuin enzyme that NAD+ powers. Without adequate SIRT1 activation, the NAD+ produced from NMN may not be fully utilised for its longevity-promoting functions. Resveratrol and NMN together create a "lock and key" mechanism: NMN provides the energy currency (NAD+), and Resveratrol ensures the enzyme that uses it is switched on.

TMG (Trimethylglycine) is included as a methyl donor to support the methylation cycle. When NMN is metabolised, it generates nicotinamide, which must be methylated before excretion. Long-term NMN supplementation without methyl support can theoretically deplete methyl groups, which are also needed for cardiovascular health and gene regulation. TMG proactively addresses this by replenishing the methyl pool. This level of formulation thoughtfulness is what distinguishes AIDEVI NMN 18000 from simpler, single-ingredient NMN products.

AIDEVI NMN 18000 is generally compatible with most common dietary supplements. It pairs particularly well with other AIDEVI longevity products, such as the AIDEVI NAD+ SUSTAIN formula for those seeking a comprehensive cellular longevity stack.

If you are taking blood thinners, diabetes medications, or any other prescription drugs, please consult your healthcare provider before adding NMN to your regimen, as NMN's effects on insulin sensitivity and blood glucose may interact with certain medications.

Store in a cool, dry place away from direct sunlight and heat (ideal storage temperature: below 25°C / 77°F). NMN is hygroscopic and can degrade when exposed to moisture or high temperatures. Keep the bottle tightly sealed when not in use. Refrigeration is not required but may extend shelf life in warm climates. Keep out of reach of children.