The Pursuit of Longevity
In the Ant-aging and wellness world, NMN (nicotinamide mononucleotide) and resveratrol are two widely popular supplements.
While they work in different ways, both can help boost vitality and longevity. A common question arises: Which supplement is superior? The short and perhaps unsatisfying answer is that it depends on your specific situation.
You can compare NAD+ to fuel, as it powers the functions of your cells. NMN helps fill up the tank, while resveratrol is like a rust-proofing spray that protects the vehicle from damage. Both are useful and beneficial to the human body.
Which option best suits your needs? Let's explore their unique effects and synergistic potential.
Hallmarks of ageing
Aging is the result of cellular damage built up over time from genetic, environmental, and lifestyle influences. This damage manifests in many forms, from visible signs like wrinkles to life-threatening diseases.
In 2013, researchers developed the "9 Hallmarks of Aging" framework to outline the key biological processes that drive aging.
One important hallmark is epigenetic changes, which are damage to the regulatory system that controls gene expression (the epigenome). DNA is the blueprint for how cells work. The epigenome is like a management team. It determines which genes turn on or off.
Damage to the epigenome causes cells to behave abnormally, leading to a range of problems. For example, liver cells can act like skin cells. This change can weaken immunity and may even lead to cancer.
Understanding these hallmarks can provide valuable insights into the aging process and potential interventions to mitigate its effects.
9 Hallmarks of Aging
Understanding sirtuins
Research on aging mechanisms suggests that targeted interventions could slow down or even reverse the aging process. A key discovery in the field is the role of sirtuins, often referred to as “longevity genes.” These genes produce proteins that help repair cellular damage and play a vital role in maintaining cellular health.
Leonard Guarente's lab at MIT first discovered sirtuins in yeast cells and later found them in mammals as well. Notably, studies have shown that increasing sirtuin activity in mice can significantly extend their lifespan.
NMN and resveratrol both support sirtuins: NMN boosts NAD+ production, which activates sirtuins, while resveratrol directly enhances their activity. Together, these compounds contribute to a broader understanding of how cellular repair mechanisms influence longevity.
Learn about Resveratrol and NMN
What is Resveratrol
Resveratrol is a natural polyphenol found in foods like grapes, red wine, berries, and peanuts. Renowned for its potent antioxidant properties, it helps protect cells from oxidative stress—a key driver of aging. Resveratrol has gained significant attention for its potential health benefits, particularly in promoting cardiovascular health, reducing inflammation, and supporting an active lifestyle.
One of its notable mechanisms is activating SIRT1. Additionally, resveratrol supports “autophagy”, the body’s natural process for clearing out damaged cells and maintaining cellular functionality. Together, these effects make resveratrol a valuable compound in the pursuit of healthier aging.
Resveratrol Food Sources
What are the Benefits of Resveratrol?
- Antioxidant and anti-inflammatory properties
- Heart health
- Neuroprotective effects
How can I increase my Resveratrol naturally?
Resveratrol is a natural compound made by plants. They produce it when germs like bacteria or fungi hurt or attack them.
Researchers have identified resveratrol in over 70 plants worldwide, and fresh grape skins contain 50 to 100 μg per gram. This results in red wine and grape juice being high in resveratrol.
We often hear about the health benefits of drinking red wine in moderation. People sometimes refer to this phenomenon as the 'French paradox.' Studies link it to better heart health.
The French eat a diet that is high in fat. However, they have low rates of heart disease. People often attribute this to their high intake of red wine.
What is NMN
NMN (nicotinamide mononucleotide) is a molecule that is essential for cellular energy production and overall health. As we age, NAD+ levels naturally decline, leading to a variety of age-related health issues.
Taking NMN can help restore NAD+ levels. This supports cell health, boosts metabolism, and increases energy production. Promoting vitality and fighting the effects of aging is important.
NMN Food Sources
What are the Benefits of NMN?
- NAD+ precursor
- Anti-aging potential
- Metabolic health
- Cardiovascular health
- Neuroprotective effects
How can I increase my NMN naturally?
NMN occurs naturally in many foods. Some dietary sources of NMN include: avocados, broccoli, cabbage, tomatoes, raw beef.
NMN VS Resveratrol
Synergistic Effects of NMN and Resveratrol
Modern lifestyles often include bad eating habits and little exercise. These can harm sirtuin genes. Sirtuins are important for cell repair and living longer.
An unhealthy lifestyle can lower sirtuin activity. However, caloric restriction, like intermittent fasting, can activate these genes. Interestingly, resveratrol mimics the effects of caloric restriction by directly activating sirtuins genes, promoting cellular repair and maintenance.
However, sirtuins also require a key resource to function: NAD+, a molecule that decreases with age. Boosting NAD+ levels is essential to maintain sirtuin activity, and this is where NMN plays an important role. NMN contributes to the production of NAD+. This boosts the body's supply and gives energy to sirtuins for their repair work.
Together, NMN and resveratrol make a powerful combination. Resveratrol activates longevity genes, while NMN provides the necessary energy for these genes to repair cellular damage. This combination targets all nine hallmarks of aging. This makes it a good strategy for healthy aging and longevity.
Dr. David Sinclair is a well-known researcher in longevity. He takes NMN and resveratrol supplements in a 1:1 ratio each morning. He has found that this combination works better than taking either one by itself.
NMN and Resveratrol: Which Should You Choose?
As you can see from the above sections, NMN and resveratrol make a great team. NMN supports healthy NAD levels, keeping cells active, while resveratrol protects cells from damage and may boost their repair rates.
If you're focused on antioxidant support and protecting your body from stress, resveratrol is essential. If you are more focused on cellular energy and returning to youthful vitality, NMN is the way to go.
However, for many people, using both can provide complementary benefits, providing energy support and preventing cell damage. No additional side effects occur.
We’ve made it easier for you to get your daily dose of NMN and resveratrol and other benefits in a capsule form by blending these two substances and other related synergistic substances together.
Legality of NMN and Resveratrol
Resveratrol is readily available as a dietary supplement through health food stores, online retailers, and platforms like Amazon. It is considered safe for general use and has no major regulatory restrictions.
NMN, however, has fallen into a legal gray area. In 2021, NMN was removed from the list of dietary supplements after a company began investigating its potential as an anti-aging remedy. This regulatory shift means that NMN is no longer sold on major platforms like Amazon, but it can still be purchased through dedicated supplement suppliers.
*Importantly, NMN was excluded from the supplement list not because of safety concerns—multiple studies and data show that it is well tolerated and considered safe—but because of commercial interests and regulatory complexities.
For those seeking NAD+ support, alternatives such as NMNH or PQQ remain widely available.
The future of anti-aging supplements
Statistics
The global market for healthy aging supplements is growing quickly, driven by the rising demand for products that promote longevity and restore youthful vitality in middle-aged women and seniors. Here are some statistics to prove the market demand:
The market is expected to grow from $1.41 billion in 2024 to $2.16 billion in 2034, at a compound annual growth rate (CAGR) of 5.9%.
North America dominates the industry, accounting for more than 40% of global revenues and is expected to reach $500.48 million by 2024.
Asia Pacific is expected to grow at the fastest rate, with a CAGR of 7.5% from 2024 to 2031, reaching $287.78 million by 2024.
Capsules are the most popular form, accounting for 60% of the market by 2024.
These trends highlight the growing interest in longevity supplements and their bright prospects in the health and wellness industry.
Latest News from Longevity Research
Longevity research is developing rapidly, with clinical trials and innovative discoveries paving the way for anti-aging solutions. The latest progress is as follows:
1. NMN clinical trial:
A 2024 randomized double-blind clinical trial studied the effects of nicotinamide riboside (NR) with and without resveratrol on patients with peripheral arterial disease.
Results showed significant improvements in physical performance, with participants supplementing with NR increasing their 6-minute walk distance by 17.6 meters compared to the placebo group.
2. Emerging anti-aging compounds:
Compounds such as NMN, resveratrol, spermidine, and fisetin are gaining attention as promising anti-aging treatments.
The mechanisms targeted by these compounds include NAD+ enhancement, sirtuin activation, autophagy stimulation, and senescent cell clearance.
3. David Sinclair’s Breakthrough:
David Sinclair’s recent research suggests that epigenetic changes caused by DNA damage and repair may be reversible, suggesting that it may be possible to “reset” the epigenome and reverse aging.
4. Personalized Anti-Aging Medicine:
Modern anti-aging medicine is increasingly personalized, increasing the effectiveness of supplements based on an individual’s genetic profile
Who can benefit from taking NMN and resveratrol?
NMN and resveratrol work well together for a wide range of people, especially middle-aged women and older adults. These two groups, as well as others, may see specific benefits from their combined use:
- Older Adults
- Seeking Anti-Aging Skincare
- Fitness Enthusiasts
- People with Inflammation
- Brain cognition is wrong
*Before starting any supplements, you should talk to a healthcare professional. This is especially true if you have health issues or take medications.
Conclusion
NMN and resveratrol are complementary supplements, each with unique benefits for health and longevity. They are not direct competitors, but rather offer a holistic approach to supporting overall health.
The combined effects of NMN and resveratrol may improve health and provide great results. This is especially true for those interested in anti-aging and vitality.
If you are a middle-aged woman who wants to feel young again, consider AIDEVI NMN. If you are an older adult looking for more energy, this product help you too. However, you should tailor the decision of whether to take NMN, resveratrol, or both to your personal needs and health goals.
