Dr. Percival Everett
	Dr. Percival Everett is a dedicated anti-aging nutrition researcher. As a former advisor to the UCLA Center for Metabolic Research, he has contributed to cutting-edge research on longevity and cellular health. He has published seven SCI publications exploring the role of nutrition in aging, with a focus on compounds that promote vitality and longevity.

When I Lost Faith in NMN, Science Changed My Mind

Last year, my family and friends, like many others, were attracted by the anti-aging effects of NMN. However, after taking it for a while, some people began to worry because of the controversy online.

Some people chose to stop using it because the FDA banned NMN supplements on sites like Amazon. They believe these products have some risks.

I decided to stop taking NMN supplements to correct this misunderstanding through my own experience.

* I always recommend consulting a healthcare professional before making any changes to your supplement regimen.

Why do people stop taking NMN? 5 real feedbacks from my friends

Type 1: I didn’t notice any changes

They expect: 

NMN is mistakenly equated with a "quick fix" that can reverse signs of aging in a few days.

Scientific facts:

You must regularly increase NAD+ levels. A study from the University of Washington in 2021 found that it takes at least 8 weeks to see changes in cells.

Visible effects (such as skin elasticity and energy) usually appear in 3-6 months, and individual differences are significant.

Type 2: I read that NMN may cause cancer

Source of misunderstanding:

Social media misrepresented a mouse experiment from 2020. This experiment used an extraordinarily high dose. No evidence exists in humans.

Now clarified:

In 2023, a human trial took place at Keio University in Japan. Participants took 250mg of NMN each day for 12 weeks. The study found no liver or kidney damage. There were also no increased cancer markers.

Another misunderstanding is that it is unscientific to discuss toxicity without looking at the dosage. It is like saying, "drinking water can cause death" just because someone drowned.

Type 3: Other supplements are cheaper

If you pick anti-aging supplements just because they are cheap, you might choose substances like NR or resveratrol. This ignores how well your body can use them. That is undoubtedly a waste of your money.

A 2022 study in "Cell Metabolism" found that NMN is 37% better than NR at raising NAD+. This is because NMN converts directly to NAD+ without needing several steps.

However, the best way is to choose supplements that interact with multiple formulas.

Read why: NMN and Resveratrol: Which is Better?

Type 4: I am worried about long-term dependence and addiction

Many friends around me have said that supplementing NAD+ will inhibit their own synthesis ability. This leads to long-term reliance on external means to supplement NAD+.

A 2023 paper from Harvard Medical School noted that exogenous NMN activates the Sirtuins gene. This activation helps improve the cell's self-repair process. Therefore, this misunderstanding naturally disappears.

Type 5: Some people on YouTube and other platforms say this is an IQ tax

The US FDA certified NMN as safe in January 2024. China’s NMPA also approved several NMN clinical studies.

Take this video as an example. However, people who have taken it for a while disagree. They shared their views in the comment section below.

Re-understanding NMN

What is NMN？

NMN is a natural nucleotide. It is a direct precursor to nicotinamide adenine dinucleotide (NAD+). NAD+ is a coenzyme found in all living cells.

NAD+ is important for many cellular processes. It helps with energy metabolism, DNA repair, and gene expression regulation. NAD+ levels naturally decline as we age, which can lead to decreased cellular function and overall vitality.

 

The Role of NAD+ in Cellular Health

Our cells need energy to function. A big part of this energy comes from metabolic processes that use NAD+. Recent research shows that keeping or restoring NAD+ levels may help fight some aging-related health issues.

For example, higher NAD+ levels are connected to better mitochondrial function. They also help regulate circadian rhythms and increase stress resistance.

When I stopped taking NMN

Spoiler alert: I feel a huge difference in my life. If you want the details, keep reading…

I don't look forward to the morning anymore

While taking NMN, my alarm went off at 7am every morning. I often woke up a few minutes early. I felt energetic all day long. I was always amazed at how easily I could exit bed without snoozing in my 50s.

Two weeks after stopping the NMN supplement, I could already feel my body starting changing. Waking up was suddenly more difficult. I wasn't staying up late but I was desperate for more time in bed, and I was tired and sleepy in the afternoon.

I have to admit that after a month, I started drinking coffee. I needed it to stay awake. I felt I needed the extra caffeine to help me get going.

I'm losing my energy

Since I started taking NMN at 35, I haven't felt a post-lunch or afternoon slump in the last ten years.

Of course, healthy lifestyle habits and diet also have a lot to do with it. I believe I also generally have a good mental focus to accommodate many productive work hours during the day.

Before I stopped taking NMN supplements, I still had energy when I got home from a busy day. I could spend time with my family and play with my children (As parents, you know how much energy it takes to be with young kids). Sometimes, if I didn’t have time to complete a workout during the day, I would continue to complete it in the evening.

But when I stopped taking it, I can honestly say that life was tough. I felt exhausted. Handling stress was hard, and my body wasn’t recovering properly.

After a busy day, all I wanted to do was lie down in bed and get some sleep. Bad habits developed, even eating junk food to relieve stress.

What conclusions did I come to?

Energy Dynamics

After you stop taking NMN, one noticeable change is how your energy levels are affected. NMN plays a key role in producing ATP. Our bodies are constantly adapting to the environment.

When you are not taking extra NMN, you will experience a temporary drop in energy. During this time, it is common to feel a slight decrease in energy or endurance.

Metabolism is a complex network of biological processes. It may change when NMN is no longer part of your daily life. These changes might not be obvious at first. Our bodies adapt by changing their metabolism to work without the supplement.

Resilience and Aging

A significant reason many people choose to take NMN is for its anti-aging abilities. Without NMN, you might see changes in how your body handles stress. It can also affect your cellular health over time. Lack of NMN may affect your body's ability to effectively support these important processes..

Immunity

Researchers link NMN to immune function, mainly due to its involvement in cellular energy production. Lowering NMN levels might require your body to modify its immune response. When I stopped taking NMN, I got sick several times during the period I stopped taking it. Especially with the flu, I clearly felt that my body's immunity was not as strong as it used to be.

Body Adapts

Our bodies are resilient and adaptable. Initially, the early effects of discontinuing NMN are gentle. Some individuals might observe slight changes immediately, whereas others might not perceive any difference whatsoever. Nonetheless, as time progresses, the body strives to restore equilibrium and adjust to the lack of NMN.

My Reboot Plan: How to Effectively Experience the Benefits of NMN

After my tough experience, I began taking NMN again. I did some tests to see if it worked.

Consult a professional:

I first consulted with a registered dietitian to develop a supplementation plan. I based this plan on my own blood test results, including NAD+ levels and inflammatory markers.

To save you the hassle, I’ve included a daily NMN calculator below. You can enter your weight below. This will give you a rough idea of ​​how much NMN you might need per day (for reference only).

Record body signals:

I monitored my resting heart rate variability (HRV) through a wearable device. In the first month, I found that my HRV did not change at all, which was a bit frustrating.

But my HRV started improving slowly in the 6th week, and finally my HRV increased by 15%. This is exciting news!

Physical management:

I also focus on "non-visible indicators." These include sleep quality and exercise endurance. I do not rely only on changes in appearance.

To be honest, my sleep quality has indeed improved a lot, and I fall asleep more easily. And I have more energy to accompany my family every day.

When I was running, it took me about 80 minutes to run 10KM when I stopped taking NMN. After taking NMN for 8 weeks, it only took me 57 minutes to run 10 km. Of course, this is also related to my persistence in running.

Other Ways to Support NAD+ Levels

I’ve also made some effective strategic lifestyle changes to naturally support your NAD+ levels and overall health, including:

Exercise:

Regular physical activity, especially aerobic exercise, naturally increases my NAD+ levels and helps reduce oxidative stress.

Intermittent Fasting: 

I looked up some research that showed caloric restriction can help maintain NAD+ levels and healthy metabolic function.

Healthy Diet:

Eating a diet full of vegetables, whole foods, and unprocessed ingredients can support your cellular function. It can also keep your insulin sensitivity healthy. You can increase NMN levels by eating certain foods.

Food Groups	Food Name	NMN content (mg/100g)
Vegetables	Edamame (unripe soybeans)	0.47-1.88
	Broccoli	0.25-0.91
Fruit	Avocado	0.36-1.60
	Tomato	0.17-0.30
Mushrooms	Shiitake mushrooms (dried)	2.08-3.72
	Flammulina velutipes	0.89-1.54
Animal foods	Salmon	0.42-0.78
	Chicken breast	0.18-0.33
Dairy	Milk (pasteurized)	0.03-0.06

The data comes from the laboratory test report of the Anti-Aging Research Center of Keio University in Japan and the Journal of Agricultural and Food Chemistry.

These positive lifestyle changes, along with NMN supplements, help me stay motivated to care for my health. This improves my energy and mood and supports my long-term health.

Conclusion

No one wants to compromise with age, at least not me! Whether it's in terms of athletic or mental abilities, we all want to perform as well as we did when we were younger, or even better. And people around me have started taking NMN supplements again because of my experience.

We often hear from others that aging is a natural process. They want us to accept this "fact." What if my personal experience offers you a way to slow down, stop, or even reverse aging? Wouldn't you take advantage of this opportunity?

NMN supplementation combined with a healthy diet and lifestyle can slow down the aging process and rejuvenate the body. If you are looking for a trusted NMN supplier, you can pay attention to the brand AIDEVI. This is not an advertisement, just an offer.

The content of this article is for reference only. This is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or health provider before starting a new health regime or plan.

Do not ignore or wait to get medical advice based on what you read on this website or any AIDEVI product. Always prioritize your body.

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*This result is based on the metabolic model developed in Nature Aging 2023. It is recommended to consult a medical professional