Nicotinamide Mononucleotide (NMN) is a promising anti-aging agent that boosts levels of an essential molecule for cellular energy generation and cellular health maintenance called Nicotinamide Adenine Dinucleotide (NAD+). Increasing levels of NAD+ with its precursor NMN has reversed age-related reductions in the function of the kidney, liver, brain, vascular, and immune systems in studies that used mice.

NMN and COVID-19

Researchers have proposed that boosting NAD+ levels can enhance the immune response to infections, including the SARS-CoV-2 infection. A non-peer-reviewed study used an NMN cocktail to treat older persons with SARS-CoV-2 infections and found rapid and dramatic improvements in clinical parameters. The patients had decreased inflammation markers and increased white blood cell (lymphocyte) counts in their blood following the administration of the NMN cocktail.

The NMN Cocktail

The NMN cocktail consisted of unspecified concentrations of over-the-counter NMN and three boosters that optimize activity of proteins dependent on NAD+ called sirtuins, which have essential roles in cellular health maintenance. The boosters included a compound isolated from sugar beets called betaine to counter NAD+ breakdown or inhibition, sodium chloride to enhance NMN absorption in the body, and zinc to increase the function of nuclear factor erythroid 2-related factor 2 (Nrf2), a protein that protects cells from cellular stress damage from injury or inflammation.

NMN administration has been shown to safely increase NAD levels in older adults. It is hypothesized that activation of the sirtuin-NAD pathway by administration of NMN may reduce the inflammatory response in tissues post-COVID-19 infection and enhance a more rapid recovery in older adults. From fighting DNA damage and oxidative stress to preventing telomere loss and supporting sirtuin activity, NMN is a smart choice for anyone looking to live a long and healthy life.