Can aging be reversed?
We may not be able to reverse aging like Benjamin Button. We also cannot drink from a magical fountain to stay young forever. However, the search for youth and energy has never stopped.
From vitamin-rich serums to creams that claim to erase fine lines, the beauty and wellness industries provide tools to slow aging. One of the most talked-about anti-aging products is NAD+ supplements. Biohackers, health enthusiasts, and several celebrities have praised NAD+ supplement.
Aging is about more than just looks, it's about maintaining health, strength, and mental clarity as we age. So, what exactly is NAD+? Is it capable of significantly aiding us in aging gracefully or reversing time?
In this article, we will explore the science behind NAD+ supplement. We will discuss their benefits and possible risks. We will also cover how to choose the right supplement.
The Science Behind NAD+ and Aging
What is NAD+
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme, a "helper" molecule required for a variety of biological processes that sustain life. Every living cell contains NAD+. It helps with metabolism by boosting energy production and supporting cell function.
NAD exists in two forms: oxidized (NAD+) and reduced (NADH).
1. In its oxidized form: NAD+ is important for turning nutrients into energy in the mitochondria. People often call these the powerhouses of the cell.
2. In its reduced form: NADH regenerates NAD through metabolic cycles, helping to maintain the balance of these processes.
Researchers discovered NAD+ in 1906. British biochemists Arthur Harden and William John Young found it while studying fermentation.
However, it was not until the 1960s that scientists like Pierre Chambon discovered how important NAD+ is for humans. They found that NAD+ plays a key role in DNA repair.
This set the stage for showing how it interacts with key proteins. These proteins help control cell repair, stress response, and aging. Examples include sirtuins and PARP.
As we age, NAD+ concentrations decrease. This leads to less efficient cells, lower energy production, and more age-related diseases. Many people understand why it has received so much attention in the anti-aging space.
What happens when NAD+ levels are low?
NAD+ depletion is driven by two main factors:
1. Reduced production: As we age, the body produces less NAD+, leading to natural deficiencies.
2. Increased demand: As we age, our cells get damaged and inflammation increases. This raises the need for NAD+ to help with DNA repair and stress responses. However, this also makes NAD+ harder to get.
As time continues, the body cannot replace its NAD+ stores fast enough. This causes systems to work poorly and affects overall health.
Low NAD+ levels can have serious effects. They often lead to metabolic problems and a higher risk of age-related diseases. These diseases include, but do not limit to:
Reduced NAD+ levels impair energy metabolism, potentially leading to obesity, insulin resistance, and type 2 diabetes.
As cellular energy production decreases, high blood pressure and heart disease are more likely to develop.
Inadequate NAD+ impairs brain health, leading to decreased intelligence and diseases like Alzheimer's.
Weakened immune functionLow NAD+ levels make it harder for the body to fight infection and inflammation. This can lead to chronic disease.
Accelerated agingReduced energy production and poor DNA repair mechanisms accelerate cellular aging, which manifests as fatigue, skin changes, and decreased vitality.
Maintaining NAD+ levels is critical not only for addressing age-related issues, but also for maintaining overall health. This understanding has sparked a lot of interest in NAD+ supplements. People see them as a way to boost levels, slow aging, and fight chronic diseases.
Can you increase your NAD+ levels naturally?
Martens once said, "If you live a healthy lifestyle, you can keep the NAD you have. This aids your cells in regenerating NAD." You can naturally increase or maintain NAD levels.
1. Prioritize a nutritious diet
Eating foods rich in NAD+ precursors is a key strategy for maintaining healthy NAD+ levels. Nutrients such as tryptophan, niacin (vitamin B3), and nicotinamide mononucleotide (NMN) are essential compounds your body uses to synthesize NAD+.
Foods such as beef, eggs, avocados, salmon, and leafy greens are excellent sources. Fermented foods like sauerkraut, kombucha, and kefir have NAD+ and its precursors. Consuming a greater quantity of these foods is beneficial.
2. Exercise regularly
Physical activity is one of the most effective natural ways to increase NAD+ levels. Studies have shown that regular exercise, including both aerobic and strength training, stimulates metabolic pathways that promote NAD+ biosynthesis. This may also explain why people who maintain an active lifestyle tend to look younger.
3. Get quality sleep
Circadian rhythms are closely tied to NAD+ levels. Frequent late nights disrupt these rhythms and can deplete your body’s NAD+ reserves. Achieving 7-9 hours of quality sleep nightly aids in your body's self-repair. It also supports healthy NAD+ production.
4. Protect your cells from damage
Avoiding harmful habits and exposures that stress your cells can help maintain existing NAD+ levels. Refrain from excessive drinking and smoking. Additionally, reduce your UV ray exposure. UV rays can damage DNA.
Your body needs NAD+ to fix this damage. Neglecting your skin can lead to a lackluster appearance and a decrease in its elasticity.
What is NAD+ supplement?
NAD+ supplement help restore NAD+ levels in the body. They may reduce some negative effects of aging.
These supplements have become immensely popular. Stars such as Jennifer Aniston and Hailey Bieber endorse them. This has made them a rising star in the growing global anti-aging market.
In 2018, the sector's value reached $52.5 billion. Analysts expect the market to grow to $83.2 billion by 2027. This shows that their products are valuable and known for their effectiveness.
NAD supplements you find in stores usually contain NAD precursors. These are substances that the body changes into NAD+. The most common precursors include:
Nicotinamide riboside (NR): a form of vitamin B3 that is easily absorbed and converted to NAD+.
Nicotinamide mononucleotide (NMN): Another popular precursor known for its efficiency in increasing NAD+ levels.
NAD+ supplements come in a variety of forms to suit personal preferences and lifestyles: pills, powders, and lozenges. Recently, researchers have developed new anti-aging products. Some of these products can directly provide NAD+ to increase NAD levels. This shows that there is still a lot to learn about how the body absorbs and uses direct NAD+.
It is worth noting that intravenous infusions (IV therapy) that can directly supplement NAD+ have been opposed by some experts. This is because there may be health and safety issues. Taking it in capsule form is currently a safer and more reliable way.
Benefits of NAD+ supplement
Researchers study NAD+ supplement more and more. They may help with the natural drop in NAD+ levels as we get older. Aging and the development of various chronic diseases contribute to this decline. This article lists some representative benefits, and a more comprehensive list of benefits can be found in other articles:
Slowing the Effects of Aging:
Research suggests that cardiovascular health may be improved by supporting vascular function and reducing inflammation. Additionally, NAD+ supplements may prevent age-related muscle loss and enhance strength, mass, and overall function. Enhanced mitochondrial performance further helps maintain cellular vitality, potentially extending healthy lifespan.
Promotes Brain Health:
Supplementing with NAD+ can reduce inflammation and oxidative stress in nerve cells, thereby providing potential neuroprotection. Early studies show that NAD+ supplementation improves biomarkers of Alzheimer's disease. It also reduces symptoms in patients with Parkinson's disease. By supporting brain cell energy production and reducing inflammatory damage.
Supports Skin Health:
Helps make skin healthier and more resilient by addressing age-related damage at the cellular level. Improves DNA repair to help skin heal from UV damage and environmental stress. This reduces signs of early aging.
Topical and oral NAD+ treatments may help with conditions like psoriasis. They can slow down the unusual growth of skin cells.
Enhances Metabolic Health:
Metabolic disorders such as obesity, type 2 diabetes, and metabolic syndrome have been linked to decreased NAD+ levels. Supplementation can improve insulin sensitivity, regulate blood sugar levels, and improve lipid profiles. At the same time, it also supports fat metabolism and muscle health, helping to improve body composition. By improving energy utilization at the cellular level.
Reduce Inflammation:
Chronic inflammation, or "inflammaging," accelerates aging and increases the risk of various diseases, including cardiovascular disease, diabetes, and cancer. Experiments indicate that it can inhibit low-grade chronic inflammation.
Protect Heart Health:
Maintain vascular health, reduce inflammation, and improve cholesterol and triglyceride profiles. In patients with heart failure, NAD+ may help heart cells use energy better. This can improve heart function and help resist heart diseases.
How does AIDEVI help you increase your NAD+ levels?
A busy lifestyle can make it difficult to follow a healthy diet and exercise plan. This can reduce NAD+ levels.
If you have a busy, stressful job and need more energy, AIDEVI's anti-aging products may be for you. They can help you improve your health in a way that fits your schedule.
At AIDEVI, we offer a range of NMN products for anti-aging. We also have new products that directly enhance NAD+ and other anti-aging solutions.
If you need a quick boost of energy and want fast results, a supplement that directly supplements NAD+ is a good choice. Professor Michael Levitt won the Nobel Prize in Chemistry in 2013. He led the research and development and continues to support it.
AIDEVI has its own R&D laboratory. It also has a production plant with many qualifications and certifications, such as FDA and GMP. Committed to being a powerful ally for your healthy life.
FAQ on NAD+ Supplement
Who should take NAD+ supplements?
Middle-aged office workers want to boost their energy quickly. Older adults aim to fight aging and regain youth. Women seek to reduce wrinkles and improve skin elasticity.
Who should avoid taking NAD supplements?
People with severe allergies to NAD+ supplement should be careful. This also applies to pregnant or breastfeeding women, children, and those with liver or kidney issues. They may face side effects from these supplements.
Are there any side effects of NAD+?
Taking NAD supplements at the doses recommended by your doctor is generally safe for most people.
A 2023 review of studies found that these supplements were safe for healthy, middle-aged, and older adults.
However, "safety information is scarce. Not enough evidence exists to say that NAD supplements are safe for pregnant women. If you have any underlying conditions or health issues, talk to your doctor before trying NAD, ”Kahn says.
As with many supplements, there is a risk of mild side effects, especially at high doses. These encompass nausea, headache, or skin redness. For most people, the risk is extremely low because we already make these molecules in our bodies.
If you experience negative side effects after taking NAD supplements, discontinue use and contact your doctor.
Do NAD+ supplements cause cancer?
At this point, there is no direct evidence that NAD+ supplements cause cancer. Researchers have found evidence that reduced NAD levels affect cancer cells. This means they may grow better with high amounts of NAD. Even so, it does not mean that NAD+ supplements cause cancer, but cancer patients should avoid using them.
Do NAD supplements genuinely work?
A lot of clear evidence shows that NAD+ supplements are useful in humans and animals. But we would like to see more peer-reviewed research in this area. For now, given their relative safety, they are worth a try.
Conclusion
Stay as young as possible, maintain good living habits, and exercise regularly. In today's society, it's hard for us to do this. That's why AIDEVI decided to create anti-aging products. We hope that you will only grow older, but your physical condition and appearance will be the same as when you were young.
If you choose AIDEVI NAD+ supplement, it means giving us a chance to make you better. Of course, before taking NAD supplements, always consult a healthcare provider. Health always comes first.
